Scholarship: Fully-funded
Degree: PhD
Nationality: International Students
Location: USA
Application deadlines: Open
Scholarship Description:
The Respiratory Functional Genomics Laboratory at Brigham and Women’s Hospital, Harvard Medical School aims to determine the function of genes identified by genome-wide association studies (GWAS) in respiratory diseases, including asthma and Chronic Obstructive Pulmonary Disease (COPD) through integrative biology approaches. The primary goal of our research is to annotate the non-coding GWAS variants to the disease genes through inter-disciplinary collaborations and characterize function of these novel diseases’ genes in vitro cell models and ex vivo lung organoid models as well as in vivo disease-relevant mouse models. We are interested in how these novel GWAS genes participate in lung injury/repair process, modulate lipid and glucose metabolism and determine innate immune response in airway and alveolar epithelial cells as well as in mesenchymal niche cells through intrinsically signaling and cross- cell communications. Through a series of integrative and cross-functional work, we aim to identify novel pathways contributing disease susceptibility and progression as novel drug targets for treatments in patients with pulmonary conditions.
Available Subjects:
- Gene regulation, CRISPR editing, chromatin interaction, epithelial biology, organoid models, cellular metabolism and/or mouse models.
- Molecular biology and NGS data analysis.
Eligibility criteria:
- Postdoctoral candidates with solid knowledge and strong skills related to gene regulation, CRISPR editing, chromatin interaction, epithelial biology, organoid models, cellular metabolism and/or mouse models as well as strong motivation to work in a dynamic and challenging research area are strongly encouraged to apply. We also encourage applications from candidates with combined skills in molecular biology and NGS data analysis.
Application Procedure:
Please submit inquires and applications including CV, the names of three references, and a cover letter to Dr. Zhou, Associate Professor in Medicine, Director of the Functional Genomics Laboratory:
rexiz@channing.harvard.edu. See more information in https://gwas2bio.bwh.harvard.edu.