Scholarship: Full award
Degree: Ph.D
Nationality: International Students
Location: USA
Application deadlines: Open
Scholarship Description:
The goal is to elucidate key, and hopefully actionable, determinants of the fate of alveolar type II (AEC2s) stem cells during injury repair, based on our recent discovery that human AEC2s transdifferentiate to metaplastic pro-fibrotic airway-like basal cells under stress (NCB, in press). The project will involve parallel transcriptional/epigenetic profiling of human AEC2s from normal and fibrotic lungs, and epigenetic comparisons with other species. Mediators of transdifferentiation will be defined in ex vivo organoids and in vivo transplantation into mice. Qualified candidates should have strong cell and molecular biology experience and interest in single cell genomic analyses using state-of-the art tools to interrogate differentiation states. Send curriculum vitae to Hal Chapman, M.D. Department of Medicine, University of California San Francisco. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status
Available Subjects:
Cellular basis of lung regeneration or progressive epithelial dysplasia and fibrosis in injured human lungs.
Eligibility criteria:
Qualified candidates should have strong cell and molecular biology experience and interest in single cell genomic analyses using state-of-the art tools to interrogate differentiation states
Responsibilities
Mediators of transdifferentiation will be defined in ex vivo organoids and in vivo transplantation into mice
Application Procedure:
Send CV to hal.chapman@ucsf.edu.