Degree: PhD or MD/PhD
Nationality: International Students
Application deadlines: Open
HIV-1 persists in quiescent CD4+ T cells and possibly tissue macrophages in infected individuals despite prolonged antiretroviral therapy. Immune escape variants achieved in the viral reservoirs present one of the major obstacles to HIV-1 eradication. To date, no broadly applicable strategy has been developed to prevent or eradicate HIV-1 infection. Our studies involve a combination of biochemical, cell biological, and physiological approaches aimed at understanding the immunobiology of HIV infection and training the human immune system to better control and/or clear HIV-1 infection. Our current research includes the roles of CARD8 inflammasome in HIV-1 infection (Science 371(6535):eabe1707), biology of the HIV reservoirs in CD4+ T cells (Immunity 47(4):766-775), and novel humanized mouse models to test immunotherapeutic strategies for eliminating HIV-1 reservoirs (Nature 15;517(7534):381-5; Science 371(6533):1019-1025).
Additional information can be found at https://sites.wustl.edu/shanlab/
Washington University School of Medicine (WUSM) has a rich history of success in research, education and patient care, earning it a reputation as one of the premier medical schools in the world. The University is internationally known for studies in infectious diseases and immunology. Additional information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs. Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.
Immunobiology of HIV infection
- PhD or MD/PhD in biomedical sciences such as immunology, virology, molecular and cellular biology, or related fields is required.
- Preferred candidates will have significant experience in immunology or virology.
- Candidates should have a publication record in peer-reviewed journals.
- The successful candidate will have the ability to work both independently and in a highly collaborative environment..
Applicants should email the following documents to Liang Shan, Ph.D. ([email protected]):
- Cover letter including a short statement of research goals
- Curriculum vitae including a list of publications
- Three references with their application