Scholarship: Full award
Nationality: International Students
Application deadlines: Open until filled
The Zhu lab studies the regulation and function of the dynamic proteostasis pathways, with a focus on the intriguing 12h ultradian rhythm of proteostasis[Zhu et al., Cell Metabolism, 2017; Pan et al., PLoS Biology, 2020;Meng et al., Nature Communications, 2020]. More recently, Zhu and colleagues uncovered that nuclear speckle liquid-liquid phase separation dynamics drives XBP1s-mediated proteostasistranscriptional program to maintain metabolic homeostasis, and protects against liver aging and non-alcoholic fatty liver diseases(Dion et al., Science Advances, 2022). For his exceptional creativity, Dr. Zhu was awarded the highly competitive and prestigious NIH Director’s New Innovator Award(https://ai.dom.pitt.edu/dr-bokai-zhu-receives-nih-directors-new-innovator-award/). The Zhu lab is currently investigating the transcriptional/epigenetic regulation as well as the physiological/pathological functions of the rhythmic proteostasiscontrol, with an emphasis on its roles in maintaining metabolic homeostasis and preventing aging-associated diseases(including NAFLD and neurodegenerative diseases). Acombination of state-of-the-art computational, biochemical, genetic, cellular, imaging and genomic approaches is currently utilized in the lab. For a detailed description of the research performed in Zhu lab, please visit http://www.bzhulab.com.
The search is primarily targeted towards scientists who recentlyfinished their PhD. Start date is immediate and flexible. Candidates should ideally have received a doctoral degree no more than 4years before the start date. Researchers with a passion in systemic and quantitative chronobiology, cell biology, metabolism and endocrinology, neurodegenerative diseases, molecular biology, gene regulation and epigenetics are welcome to apply.
Studying nuclear condensates in transcriptional regulation of proteostasis, metabolism and aging
Expertise in any of the following areas is highly valued:
- • In vivo mouse circadian and hepatic metabolism techniques, including IP and tail vein injection techniques, CLAMS system to study energy expenditure, and various metabolic phenotyping.
- • Experiences in using iPSC to study cellular basis of neurodegenerative diseases, experiences with mouse models of Tau and/or Aβ neuropathology.
- • Molecular biology, biochemistry and experiences in the field of transcriptional regulation of gene expression, functional genomics, chromatin biology, epigenetics, with expertise in performing ChIP/CUT&RUN assay, generating and analyzing next-generation sequencing dataset, etc.
- • Cell biology with expertise in quantitative imaging such as fluorescence time-lapse microscopy, super-resolution microscopy, and image analysis.
To apply, please send a detailed CV and contact information of three referees to Dr. Bokai Zhu at [email protected].