Nationality: International Students
Application deadlines: Open until the position is filled
Our research aims to understand the roles of mammalian enzymes play in physiological and pathological processes and to use this knowledge to identify novel therapeutic targets for the treatment of human diseases. In particular, we are interested in a class of epigenetic modification enzymes called sirtuins, which are involved in protein post-translational modification and have important biological functions. We take a highly integrative chemical biology approach to study the enzymology, identify the modified protein targets, and study the biological significance of the modification. We also develop small molecule regulators targeting these enzymes as therapeutics for age-related diseases and cancer.
Biochemistry, Molecular and Cellular Biology, Chemical Biology or a related discipline
The ideal candidate should have a PhD in Biochemistry, Molecular and Cellular Biology, Chemical Biology or a related discipline, and have experience with genetically engineering bacteria, protein purification, enzymatic assays as well as cell biology techniques. Additional knowledge of the following techniques is highly desirable: isothermal titration calorimetry (ITC), Mass Spectrometry and/or X-ray crystallography. The successful applicant will have a strong scientific record, excellent communication skills, ability to work independently and as part of team, and willingness to help mentor junior scientists.
Interested applicants should email cover letter describing research experience and interests, CV with publication list, and contact information of three references to:
Yana Cen, PhD Assistant Professor, Department of Medicinal Chemistry, Virginia Commonwealth University, 800 E Leigh Street, Suite 212, Richmond, VA 23219, [email protected], 804-828-7405