Scholarship: Full scholarship
Degree: PhD, MD
Nationality: International Students
Application deadlines: Open
The Xu laboratory studies the molecular and cellular mechanisms of human brain development and the pathogenesis of neurological disorders, focusing on human neurons, microglia and neuro-immune interactions using human induced pluripotent stem cell (hiPSC) models. Our research employs multidisciplinary approaches including stem cell reprogramming, molecular and cell biology, CRISPR/Cas9 gene editing, bulk and single cell RNA sequencing, patch clamp recording, pharmacology, animal behaviour and various imaging techniques. Our recent studies have successfully generated a hiPSC-based disease modelling system, including in vitro brain organoids and in vivo human-mouse chimeric brain models, to interrogate human neuronal and microglial function in brain development and neurological disorders, and identified potential therapeutic targets. (Cell Stem Cell. 2019, PMID: 31130512; Nature Communications. 2020, PMID: 32221280; Stem Cell Reports. 2021, PMID: 34297942). For more information, please visit our website: https://www.ranjiexulab.com/
Purdue University is a major research university with a global reputation for excellence located in West Lafayette, Indiana, an affordable and picturesque college town. The institution enjoys convenient access to other major cities such as Chicago (two hours away) and Indianapolis (one hour away). Purdue University is committed to promoting diversity and fostering a workforce that represents a broad range of backgrounds and perspectives.
- Neurodegenerative (Alzheimer’s disease and related dementias) and neurodevelopmental disorders (autism).
- For postdoctoral positions, successful candidates are expected to have a PhD and/or MD in the biological sciences, neuroscience, stem cells, immunology or a related field. Candidates are also expected to have strong problem-solving, oral and written communication skills, and the ability to work independently and collaboratively.
To apply, please send a current CV and a cover letter describing your research interests to Dr Ranjie Xu ([email protected]).