Degree: Ph.D. or M.D/Ph.D
Nationality: International Students
Application deadlines: Open
Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to bone marrow failure or leukemia. Dr. Tong’s laboratory studies various signaling pathways in hematopoietic stem cells, bone marrow failure, and leukemia. Her laboratory recently identified a novel E3 ubiquitin ligase that plays a critical role in ribosome assembly and thereby controls hematopoietic stem cell regeneration. This postdoctoral fellow position will focus on studying the mechanisms by which ubiquitin-dependent signaling and ribosome biogenesis in regulating stem cells and investigating how failures in these processes impact hematopoietic stem cell function that leads to bone marrow failure and/or leukemia. Furthermore, this postdoctoral fellow will perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases.
CRISPR screens in hematopoietic stem cells to study ribosome biogenesis and ubiquitin signaling
- Candidates should have a Ph.D. or equivalent degree and experience with investigating biochemistry, cell biology, molecular biology, as well as mouse models.
- Highly motivated candidates with publication records are encouraged to apply.
Please email or send applications with a brief statement of research experience and interest, CV, and contact information for at least two references to: [email protected]